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  • Estimating genotype frequencies

    Describing the frequencies of genotypes with more than a few loci is diffiult, because there are so many possible genotypes.  However, if associations between genes ("linkage disequilibria") are generated by some kind of population mixing, then they take on a particularly simple form.  The strength of associations, and the genotype frequencies, can be estimated using a Monte Carlo method.

  • For example, this estimates a matrix of linkage disequilibria for data held in an array Data[1063], using the [Graphics:../Images/index_gr_22.gif] algorithm: 

    • [Graphics:../Images/index_gr_23.gif]
    [Graphics:../Images/index_gr_24.gif]

    There is also a simpler method based on the sample moments; this extends to inferences about mated pairs from samples of the families which they produce.

  • For example, this estimates associations among genes in the parents from a set of data on families, held in familydata: 

    • [Graphics:../Images/index_gr_25.gif]
    [Graphics:../Images/index_gr_26.gif]

    There is also a simpler set of algorithms for estimating pairwise disequilibria using maximum likelihood.

    Converted by Mathematica      April 16, 2002

    This site is no longer maintained and has been left for archival purposes

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