The packages provide a general mathematical framework for the evolution of systems of many genes; this is applied to various examples of diploid sexual populations.  Natural and sexual selection, sex-dependent recombination, migration, and non-Mendelian inheritance are included.  An extension to random genetic drift is also outlined.

For example, these rules describe a complete life cycle, including a cytoplasmically inherited locus i:

The cytonuclear association in female gametes decreases by

This is the three-way association between two autosomal loci and a cytoplasmic locus: